22160 R for bio data science
Aim: Investigating hepatic gene expression by comparing expression levels across:
| - Healthy individuals - Patients with NAFLD - Patients with cirrhosis ### Data | {style=“width:80%;”} |
Workflow Diagram
Aim: First analysis of our datasets
| - Distributions are fairly equal throughout our data - Sick people are older on average - No significance in disease between men and women | {style=“width:85%”} |
Some plots
Compare gene expression levels between groups using DESeq2 Output: Global Mean - Fold-change - Adjusted-p-value


Aim: Investigating hepatic gene set enrichment
| - C11 hepatocytes is a subtype of hepatocytes (1 of 3) - Hepatocytes produces hepatokines (hormone involved in metabolic regulation) - Some therapies try to promote hepatocyte regeneration | {style=“width:100%”} |
Group 20